For instance, dysregulation of miR-143-3p, miR-133, miR-301a and miR-597-5p eventually contributes to Fra-2 overexpression in osteosarcoma [4], hepatocellular carcinoma [5], non-small cell lung cancer [6] and colorectal carcinoma [7], respectively. The gene discussed is FOSL2; the disease is osteosarcoma.