Since tamoxifen can decrease mRNA transcript of Fra-1 in MCF-7 cells [41], we could hypothesize that the modulation of genes in cancer-associated fibroblast might be coordinately achieved by tamoxifen-induced Fra-1 and Fra-2 inhibition, involving differences in AP-1 complex motif recognition by Fra-1 and Fra-2 [42]. This evidence concerns the gene JUND and cancer.