In preclinical models of NSCLC, Wnt/β-catenin signaling induces Fra-2 activation and ARID5A repression in macrophages, driving the expression of M2-specific genes (CD163, CD206, IL1R1 and TGFβ) and leading to the differentiation toward M2-phenotype [111]. The gene discussed is TGFB1; the disease is non-small cell lung carcinoma.