In the current investigation, there was a marked elevation in the SOD, GPx, and CAT levels and a significant decline in MDA level in brain homogenate of CSO pre and post-restrained rats, indicating the modulator effect of CSO treatment to enhance the balance between the production of antioxidants and oxidants to vanish the oxidative damage and promote homeostasis and this effect may be due to their high content of ALA or omega-3. Here, SOD1 is linked to craniosynostosis.