Here, we found that seven ERS-related lncRNAs (ACTN1-AS1, AP003774.2, DOCK8-AS1, DDX11-AS1, MIR924HG, MIR9-3HG, and AL451085.2) were differentially expressed between tumor and normal tissues and associated with the OS of HNSCC patients. The gene discussed is ACTN1; the disease is neoplasm.