However, statistically significant differences were observed between the two groups in terms of age, SLE disease duration, epilepsy, fever, serositis, oral ulcers, alopecia, pulmonary hypertension, interstitial lung disease, SLEDAI-2K score, anemia, proteinuria, microscopic hematuria, hypoalbuminemia, creatinine, urea nitrogen, lactate dehydrogenase (LDH), ESR, CRP, IgM, IgA, and infection (Tables 1, 2). This evidence concerns the gene ESR1 and Fever.