We established that many of these receptors had altered profiles in GBM samples included in the TCGA PanCancer dataset, including upregulation of S1PR2, LPAR4, EDNRA, FFAR4, HTR7, and OXGR1. Most strikingly, however, GNA12 was altered in almost one third of the profiled samples, a higher rate than that observed for any of the Gα12-coupled GPCRs. This evidence concerns the gene EDNRA and glioblastoma.