GNA12 and glioblastoma: GPCRs that couple to G⍺12 and are altered in ≥ 5% of patients are shown in Fig. 1A. Notably, most GPCRs were overexpressed in fewer patients and in subsets of patients distinct from those with elevated GNA12. Overall expression of GNA12 mRNA in GBM based on TCGA analysis by Gliovis was 2.2-fold higher than in normal brain (Fig. 1B).