RHOA and central nervous system cancer: Notably, however, glioma stem cells in early passage culture tend to revert to a less aggressive phenotype with a different molecular signature than that of their parental GBM39, and the addition of serum, which contains activators of GPCRs coupled to G⍺12/13 and to RhoA mediated gene expression6, stimulates their transition to a more mesenchymal phenotype24.