CASP3 and malignant colon neoplasm: Evidence shows that lobaplatin could trigger caspase-3 activation and GSDME cleavage, as well as activate the ROS/JNK/Bax mitochondrial apoptosis pathway, which increases cytochrome c release, indicating that GSDME-dependent pyroptosis is a potential mechanism by which loplatin eliminates colon cancer cells [48].