Li et al. found that Photodynamic therapy (PDT) could induce pyroptosis in esophageal squamous cell carcinoma (ESCC) by modulating the PKM2/caspase-8/caspase-3/GSDME pathway, indicating that the clinical implementation of PDT in ESCC may have significant implications [125]. The gene discussed is PKM; the disease is esophageal squamous cell carcinoma.