E3 ligase complex CRL4ADCAF1-mediated degradation of the ribonuclease Dicer1 promotes CRC growth [13], while β-TrCP1-induced ubiquitination and degradation of HuR, an oncoprotein that binds to proliferation-related RNA, suppresses CRC cell growth [14]. The gene discussed is DICER1; the disease is colorectal carcinoma.