PKM and colorectal carcinoma: E3 ligase CHIP destabilizes PKM2 via mediating its ubiquitination and degradation [33], whereas TRIM29 triggers the K48-linked ubiquitination and proteasomal degradation of PKM1 to decrease PKM1/PKM2 ratio, motivating PKM2-mediated aerobic glycolysis to become the dominate energy source of CRC cells [34].