Many E3 ligases are considered potential diagnostic markers and survival predictors of CRC patients, for instance, patients with stage II/III CRC and high-expression of an E3 ligase of c-Myc, membrane-associated guanylate kinase, WW and PDZ domain containing 3 (MAGI3), had a satisfying recurrence-free survival (~80%, 5-year) and with no necessity for further adjuvant chemotherapy [116]. This evidence concerns the gene MAGI3 and colorectal carcinoma.