The major roles of HSP27 include regulation of protein folding by chaperone function, protein degradation, maintenance of the cytoskeleton, regulation of the cell cycle, immune response, promotion of cancer, induction of resistance to anticancer drugs, aging, biomarkers of disease, exacerbation of neurodegenerative diseases, development, and differentiation6–9,27–36. The gene discussed is HSPB1; the disease is neurodegenerative disease.