CXCL10 activated CXCR3+ effector T cells, which stimulated T cells to release more CXCL10, further enhancing the chemoattraction of CXCR3+ T lymphocytes and antigen-specific cytotoxic T lymphocytes to gliomas [63] (Fig. 3). This evidence concerns the gene CXCR3 and central nervous system cancer.