CXCR3 and central nervous system cancer: In GBM, available evidence appears to favor the role of CXCR3-A receptor as the predominant CXCR3 isoform, whereas CXCR3-B is often downregulated in glioma cells in order to maintain a higher CXCR3-A: CXCR3-B ratio for tumor growth [25].