Regarding CD8+ T cells, Tc infection resulted in 40%–72% decline in CD8+Tnv cells followed by 1187%–2242% expansion of CD8+Tem irrespective of pregnancy and vaccination status, and maximal increase in CD8+ Tem/Tnv ratio was observed in vaccinated/infected pregnant mice (Fig. 3m–o, p < 0.01–0.0001). Here, CD8A is linked to infection.