In the therapy of NSCLC BM, osimertinib, as a representative third-generation epidermal growth factor receptor (EGFR)—tyrosine kinase inhibitors (TKIs) drug, demonstrated significantly enhanced BBB permeability compared to previous generations and delayed the trend of new CNS metastases in patients without baseline BM [37, 38]. Here, EGFR is linked to non-small cell lung carcinoma.