SERPINE1 and gastric cancer: Our results revealed that knockdown of Serpin E1 in CAFs significantly suppressed colony formation, invasion, and migration of AGS cells (Fig. 1F, H), whereas overexpression of Serpin E1 in CAFs produced opposite effects (Fig. 1G, I), suggesting that Serpin E1 derived from CAFs promoted a malignant phenotype of GC cell in vitro.