In LNCaP-ADR cells, we observed upregulation of several genes associated with the arginine and proline metabolic pathways, including MAOA, ALDH3A2, ALDH2, ARG1, CKMT2, and CNDP1. MAOA has been associated with perineural invasion in prostate cancer cells [27]. The gene discussed is ARG1; the disease is prostate cancer.