Additionally, the hub genes associated with the common pathogenesis of COVID-19 and cardiovascular diseases identified in this study, namely PTPRC, ITGAX, GZMB, IL10RA, TLR7, CSF1R, CCR7, CCR5, ITGAL, and IL2RB, are all associated with innate immune and inflammatory responses. Here, GZMB is linked to cardiovascular disorder.