TLR7 and cardiovascular disorder: Then, using the CytoHubba plugin based on four algorithms, 11 genes (PTPRC, CD19, ITGAX, GZMB, IL10RA, TLR7, CSF1R, CCR7, CCR5, ITGAL, and IL2RB) were identified as hub genes and considered the core targets of COVID-19 and cardiovascular diseases (Fig. 4C and Table 1).