The results demonstrated that CSF1R, CCR5, ITGAL, IL10RA, and ITGAX had the highest association with cardiovascular diseases, and CSF1R, CCR5, TLR7, ITGAL, and CCR7 showed the highest correlation with heart diseases, while CSF1R, CCR5, ITGAL, PTPRC, and CCR7 showed the highest correlation with vascular diseases (Fig. 7A). This evidence concerns the gene ITGAL and cardiovascular disorder.