Semaphorin 3A, a gene in the same family and located in the same chromosome of Semaphorin 3E, was nominally associated (second top hit) with HT in the original GWAS [17], and it has been related to vascular permeability of the blood-brain barrier and brain damage after cerebral ischemia in murine models [55]. The gene discussed is SEMA3A; the disease is hematocrit.