It is also important to note that for some phenotypes, such as Ellis-Van Creveld syndrome, there are pairs of genes associated with these gene-phenotype dyads that are in tight linkage with each other (EVC and EVC2 on chromosome 4 [MIM: 604831 and MIM: 607261])29 so that co-segregation evidence for a locus can include variants in both the linked genes. Here, EVC is linked to Ellis Van Creveld syndrome.