SLC26A4 and Pendred syndrome: For example, if the testee is a newborn with hearing loss and a homozygous SLC26A4 variant (MIM: 605646) but no temporal bone imaging has been performed, but there is another case in the literature of a child with hearing loss and enlarged vestibular aqueducts of the inner ear who has the same variant in the SLC26A4 gene for Pendred syndrome (MIM: 274600), +2.5 points for PP4 can be awarded for the published case based on the 50% diagnostic yield for children with hearing loss and this inner ear finding.23