We examined their unique cell morphology characteristics (A) and analyzed a wide range of tumor markers (B), including the PD‐1/PD‐L1 status, PD‐L2 expression, EMT markers (vimentin, E‐cadherin, and N‐cadherin), oncogenes (TWIST and Snai1), and the HNC stem cell marker CD44. The gene discussed is PDCD1; the disease is neoplasm.