We examined their unique cell morphology characteristics (A) and analyzed a wide range of tumor markers (B), including the PD‐1/PD‐L1 status, PD‐L2 expression, EMT markers (vimentin, E‐cadherin, and N‐cadherin), oncogenes (TWIST and Snai1), and the HNC stem cell marker CD44. This evidence concerns the gene CD44 and neoplasm.