IGFBP3 and cancer: He et al. found that GSDMB binds to signal transducer and activator of transcription 3 (STAT3) and increases the phosphorylation of STAT3, which increases the expression of hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), enolase 2 (ENO2), and insulin-like growth factor-binding protein 3 (IGFBP3) to enhance glycolysis in BCa cells and promote cancer cell proliferation [69]; in addition, they also demonstrated that ubiquitin-specific peptidase 24 (USP24) interacts with GSDMB and prevents GSDMB degradation in BCa cells [69].