CASP1 and posterior cortical atrophy: reported that the expression of NLRP12 was significantly higher in PCa tissue than in adjacent benign tissue and that NLRP12 may play an important role in activating NF-κB and IL-1β signalling and its association with the pathogenesis and progression of PCa [75]; they indicated that NLRP12 can upregulate caspase-1, IL-1 β, and IL-18 to promote the occurrence and progression of PCa.