SIRT1 and liver dysplastic nodule: Li et al. found that the expression of p-NF-κB, ASC, cleaved-IL-1β, NLRP3, cleaved-caspase-1, and GSDMD-N was elevated in a DN mouse model [64]; in addition, they confirmed that geniposide (GE) may inhibit the development of DN via the APMK/SIRT1/NF-κB pathway [64].