RT-qPCR showed that SERPINE1 expression in CML CD34+ cells was significantly suppressed by shSERPINE1#1 (Fig. 4A), which led to significant reduction of CFC production of CML CD34+ cells and hypersensitivity of these cell upon IM treatment (Fig. 4B, C). Here, SERPINE1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.