Importantly, our real-world cohort of patients was similar to other cohorts described in the literature and the US, with regard to rates of HPV-positivity (9 patients; 81.8%) and mutations in PIK3CA (5 patients; 45.4%) which is one of the most commonly mutated genes in SCCA.17,18,24 The most frequently mutated “somatic—potentially actionable” and “somatic—biologically relevant” genes in tumor tissue among patients in our cohort were PIK3CA (4, 5, 9, 10, and 11) and CYLD (4, 6, and 7), respectively. The gene discussed is CYLD; the disease is neoplasm.