PRKAA2 and colorectal carcinoma: Consistent with recent findings that carnitine palmitoyl transferase 1A (CPT1A) mediated FAO activation increases the lung metastasis ability of colorectal cancer (CRC) cells [58], we confirmed that the RGCC-PLK1 mediated phosphorylation of AMPKα2 activates FAO, which is required for lung metastatic TNBC cells to maintain redox homeostasis and cell survival ultimately resulting in tumor metastasis.