Consistent with recent findings that carnitine palmitoyl transferase 1A (CPT1A) mediated FAO activation increases the lung metastasis ability of colorectal cancer (CRC) cells [58], we confirmed that the RGCC-PLK1 mediated phosphorylation of AMPKα2 activates FAO, which is required for lung metastatic TNBC cells to maintain redox homeostasis and cell survival ultimately resulting in tumor metastasis. Here, PRKAA2 is linked to colorectal cancer.