Nonetheless, over 25 causative genes have been reported, of which C9orf72 (chromosome 9 open reading frame 72), SOD1 (superoxide dismutase 1), FUS (fused in sarcoma RNA-binding protein), TARDBP (TAR DNA-binding protein), VCP (Valosin containing protein), and PFN1 (Profilin 1) are implicated in about 60–70% of familial ALS cases and around 10% of sporadic ALS cases (for a comprehensive genetic ALS review see [18]). Here, PFN1 is linked to amyotrophic lateral sclerosis.