APP and Alzheimer disease: Additional studies from the Pre-Symptomatic Evaluation of Experimental or Novel Treatments for AD (PREVENT-AD) and Dominantly Inherited Alzheimer’s Disease Network (DIAN) have implicated the posterior cingulum as impaired in early-onset dominantly inherited AD, where disease is caused by one or more autosomal dominant mutations in the PSEN1, PSEN2, or APP genes [14].