In addition, we noted that the clinical data was associated with intestinal flora, with Cystobasidium and DTU089 genera showed demonstrating a significant positive correlation with RF, and DAS28 being positively correlated with Issatchenkia genus and CRP expression levels and negatively correlated with Sutterella. Correlation analysis revealed that plasma metabolites are significantly dysregulated in RA patients and correlate and interact with intestinal flora and clinical features. This evidence concerns the gene CRP and rheumatoid arthritis.