E2F1 and hypopharyngeal carcinoma: Furthermore, Zheng et al. [6] showed that ACP extract also has a certain inhibitory effect on hypopharyngeal carcinoma, which can block E2F transcription factor 1 (E2F1)-mediated MNX1 antisense RNA 1 (MNX1-AS1), which in turn can have anti-proliferation, invasion, metastasis, and pro-apoptosis effects.