GSK3B and colonic neoplasm: However, our study has the following limitations: The relevant information included in the existing drug and target gene databases may be incomplete, which reduces the credibility of the prediction results; the role of ACP in the regulation of GSK3B downstream signaling molecules needs to be further investigated; and the present study only addressed the apoptosis-inducing effect of ACP in colon cancer cells and did not delve deeper into other roles of ACP on CRC such as invasion and metastasis.