Of note, the cancer group had higher percentage of CD3+CD8+ CTL (median: 24.7% vs. 22.8%, p = 0.0003, Fig. 1E) and lower ratio of CD4+/CD8+ T cells than the healthy control (median: 1.496 vs.1.67, p = 0.0007, Fig. 1F). The gene discussed is CD8A; the disease is cancer.