CD274 and neoplasm: In addition, the reduction in tumor volume was more pronounced in CT26wt tumors with low basal (PD-L1low) and only weakly inducible PD-L1 expression (Fig. 5D) than in MC38wt tumors with high basal (PD-L1high) and more pronounced inducible PD-L1 expression (Fig. 5A).