CD274 and neoplasm: B16-F10wt and 4T1wt tumors, which were not susceptible to AIFN−γ-mediated PD-L1 induction in vitro (Fig. 2G and H), did not show a significant reduction in tumor volume in the NaHCO3 -treated experimental group compared to the untreated control group (Fig. 5F and G).