Cell-intrinsic, genetic characteristics of the respective cancer cells, such as 9p24.1 amplification leading to increased Janus kinase 2 (JAK2) and PD-L1 expression [9] or oncogenic RAS stabilizing the Pdl1 mRNA [10], explain differences in PD-L1 expression among tumor types. The gene discussed is JAK2; the disease is neoplasm.