Specifically, four loci, namely SLC39A8 in 4q24 for FEV1-GORD, MIR4456 in 5p15.33 for FVC-GORD, LOC100422212 in 1q23.3 for FEV1/FVC-IBS, and COP1 in 1q25.2 for FEV1/FVC-IBS, were not associated with lung function or GIT disease in the original GWASs. The gene discussed is COP1; the disease is digestive system disorder.