TYK2 and irritable bowel syndrome: In the aforementioned colocalization analysis, we found that a missense variant in TYK2 was colocalized for FEV1/FVC and IBD (rs12720356, PPLACO = 1.38 × 10− 8, PP4 = 0.829, Figs. 3B and 4D-F and Additional file 1: Table S4).