CAV1 and type 2 diabetes mellitus: In fact, results of the western blotting assay (Fig. 5F, I, K, M) and co-immunoprecipitation (Co-IP) confirmed cav-1 interacts with GSK3β and inactivates GSK3β by phosphorylation on Ser9 residue in a T2DM mouse model (Fig. 5J).