GSK3β has already been pointed out to be activated in either T2DM-affected hippocampus or high glucose-treated human SK cell lines owing to dephosphorylation at serine 9, which is essential to prevent Drp1 phosphorylation on Ser616 under T2DM condition in vitro and in vivo [15, 56, 57]. Here, GSK3B is linked to type 2 diabetes mellitus.