In tumors, YTHDF1 promotes the translation of m6A-modified Wnt family member 6 (WNT6) and frizzled class receptor 9 (FZD9) mRNAs, leading to aberrant activation of their downstream signaling pathways, which play a crucial role in CRC proliferation, invasion and metastasis [100]; YTHDF2 enhances the translation of OCT4 (oncogene) mRNA in an m6A-dependent manner and promotes hepatocellular carcinoma progression [101]. Here, FZD9 is linked to colorectal carcinoma.