ASB2 and acute myeloid leukemia: In addition, FTO can destabilize mature mRNA and promote acute myeloid leukemia (AML) progression by reducing the m6A abundance of RARA and ASB2 mRNA transcripts [88], as well as increasing mRNA stability by downregulating m6A in the transcripts of MZF1, resulting in the progression and metastasis of lung squamous carcinoma cells [89].