In contrast, UBE2C is highly expressed in lung cancer [12], esophageal adenocarcinomas [13], liver cancer [14], nasopharyngeal carcinoma [15], and breast cancer [16], demonstrating that UBE2C may be involved in carcinogenesis and play an essential role in tumorigenesis and cancer progression [17]. This evidence concerns the gene UBE2C and esophageal adenocarcinoma.