Subsequently, we found that 10 ICD-related genes (ATG5, BAX, FOXP3, CALR, high mobility group box 1 [HMGB1], heat shock protein [HSP]90AA1, PDIA3, IL-10, NT5E, and PIK3CA) were up-regulated, while 19 genes (CASP1, CD4, CD8A, CD8B, IL-6, LY96, MYD88, NLRP3, CXCR3, ENTPD1, IFNGR1, PRF1, TLR4, ILR1, IL1B, IFNB1, IL17A, and TNF) were down-regulated in LUSC tumor tissues (Fig. 1 and Figure S1). This evidence concerns the gene PIK3CA and neoplasm.