Interleukins generally play a crucial role in CRC [72]: IL-6 facilitates angiogenesis, migration and proliferation [73, 74]; high serum IL-8 contributes to growth and progression of CRC [75] and is even associated with resistance to chemotherapy, an important pillar of CRC treatment besides surgery [76–78]. This evidence concerns the gene CXCL8 and colorectal carcinoma.