Among the docking results, quercetin effectively bound to the most hub targets and was the most potential ingredient to become a therapeutic drug acted on osteosarcoma, while among the hub targets, PPARG, RXRA, and ESR1 were able to effectively dock with the most drug ingredients and were the most promising therapeutic targets when Radix Astragali acted on osteosarcoma. The gene discussed is RXRA; the disease is osteosarcoma.