The targets that improved the overall survival of sarcoma patients when gene expression was upregulated included Caveolin-1 (CAV1), Estrogen receptor (ESR1), Retinoblastoma-associated protein (RB1), RXR-alpha (RXRA), Signal transducer and activator of transcription 3 (STAT3), and Tumor necrosis factor (TNF). Here, TNF is linked to sarcoma.