Studies have shown that patients with overweight or obesity (excluding morbid obesity) have a 60-day reduction in mortality compared to those with normal BMI35, This may be attributed to the increased activity of the renin-angiotensin system36 and the ability of lipoproteins and adipocytes to inhibit the release of harmful inflammatory mediators37,38. Here, REN is linked to obesity due to melanocortin 4 receptor deficiency.