Consistent with previous reports, TP53 was the most frequently mutated gene in −5/del(5q) patients (37 mutations in 35 specimens) [2] and presented an excess of mutations in the −5/del(5q) cohort when compared to other AML or to CK AML without −5/del(5q) (p < 1e–04 and p < 0.001, respectively; Fig. 1B and Table S1), suggesting a cooperative effect with the deletion. Here, TP53 is linked to acute myeloid leukemia.