Here, using whole genome sequencing (WGS) combined with comparative transcriptomic approaches on the Leucegene cohort (https://data.leucegene.iric.ca/), we identified DELE1 (Death Ligand Signal Enhancer) – located in the CDR and coding for a protein associated with the inner mitochondrial membrane – as the most consistently under-expressed gene in −5/del(5q) AML, over other currently known culprits. Here, DELE1 is linked to acute myeloid leukemia.