TF and cancer: These polymer nanoparticles (PMNP-VCR-FA-TF) were designed in a way to be capable of delivering a significant dose of VCR chemotherapeutic drug to Y79 retinoblastoma cancer cells based on key advantages including an average size of 80 nm (Table 1) and the use of two ligands, i.e., folic acid and transferrin (Fig. 2).