Also, due to the overexpression of folate receptor (in ovarian cancer, colon cancer, epithelioid carcinoma of the cervix and epidermoid carcinoma of the larynx, brain)43,44 and transferrin receptor (in breast, bladder, lung adenocarcinoma and chronic lymphocytic leukemia cells)45,46 in different types of cancer cells, this nanoplatform could be used for loading different chemotherapeutic agents and deliver drugs to different tumors. Here, TFRC is linked to malignant colon neoplasm.