Deconvolution analysis using lung cancer single-cell RNA-seq (scRNA-seq) data40 also indicated that the proportion of cytotoxic lymphocytes, including CD8 + T, NK and NKT cells, increased in the Noguchi type B stage (Supplementary Figs. S7d and S7e; the association of immune features with other omics factors41 has been discussed in Supplementary Fig. S7). The gene discussed is CD8A; the disease is lung carcinoma.