Consistent with these data, Gene Set Enrichment Analysis (GSEA) of c-Kit+ BM cells demonstrated enhanced myeloid-lineage development program and reduced expression of leukemia-associated pathways involved in MYC activation24 and ribosomal biogenesis72 with Brd9 deletion (Fig. 7i and Supplementary Fig. 12d) as in Fig. 3d and Supplementary Fig. 4f. The gene discussed is MYC; the disease is leukemia.