INS and Insulin resistance: On one hand, higher adherence to the SEAD was cross-sectionally associated with lower levels of C-reactive protein, triglycerides, insulin, insulin resistance, and systolic blood pressure.8 On the other hand, 3-year cumulative adherence to the SEAD was associated with a 14% lower risk of 10.9-year all-cause mortality in participants ≥60 years.15