Previous studies demonstrated an association between higher expression ofLEF1 with the expression of ER/PR and activation of the Wntpathway in luminal subtypes, as well as a negative correlation betweenLEF1 and HER2 expression, indicating that LEF1tends to mediate tumor cell invasion mainly in tumors positives to ER/PR and lackingHER2 over-expression (Nguyen et al., 2005;Lim et al., 2011; Lamb et al., 2013). This evidence concerns the gene ESR1 and neoplasm.