In breast cancer, TCF4 is also suggested to playa role in tumor suppression (Shulewitz et al.,2006; Ravindranath et al., 2011),with low expression of TCF4 being related to chemoresistance inbreast cancer xenograft models via cell cycle deregulation (Ruiz de Garibay et al., 2018) and to metastasis, having its lowexpression accentuated in breast-to-brain metastasis (Mamoor, 2021). The gene discussed is TCF4; the disease is neoplasm.