LEF1 and TCF4 dysregulated expression, forexample, was associated to cell proliferation and invasion through Wnt pathwayalterations (Nguyen et al., 2005; Ravindranath et al., 2011; Sergio et al., 2020); while TCF3 was associatedwith tumor growth, proliferation, and stem cell self-renewal (Slyper et al., 2012; Jia etal., 2020), and TCF7 to brain-seeking breast metastasis (Park et al., 2015). Here, TCF4 is linked to neoplasm.