High expression of LEF1 was previously correlatedwith poor prognosis in several cancer types, like oral squamous cell carcinoma(Su et al., 2014), nasopharyngealcarcinoma (Zhan et al., 2019), and lungcancer (Bleckmann et al., 2013), however, asobserved in colorectal cancer (Kriegl et al.,2010), our survival analysis indicated LEF1 lowexpression to be significantly associated with poor OS, DFS, and DMSF rates.Interestingly, LEF1 had a lower expression in HER2 enriched andbasal-like, the more aggressive subtypes. The gene discussed is ERBB2; the disease is oral cavity squamous cell carcinoma.