LEF1 and Familial prostate cancer: Moreover, the expression of LEF1/TCF transcription factors can beassociated with prognosis and treatment response in various cancer types, such ascolorectal and liver cancer (Lin et al.,2011; Li et al.,2014; Anwar et al., 2020), oralsquamous cell carcinomas (Su et al., 2014),acute lymphoblastic leukemia (Fischer et al.,2015), prostate cancer (Chen etal., 2018), and lung cancer (Zhu et al., 2015).