It has been reported thatLEF1, TCF4, and TCF7 areinvolved in the maturation and malignant transformation of thymocytes, developmentof natural killer and T cells, and through Wnt pathway, tumor infiltration andimmune evasion (Yu et al., 2012; Haseeb et al., 2019; Crispin and Tsokos, 2020). The gene discussed is TCF4; the disease is neoplasm.