TCF4 is known as a tumor suppressor in some cancer types: In coloncancer, loss of TCF4 leads to tumorigenesis via dysregulation ofproliferation (Angus-Hill et al., 2011) andmetastasis (Anwar et al., 2020), and inmedulloblastoma, in vitro over-expression of TCF4 suppressed cellproliferation and growth (Hellwig et al.,2019). Here, TCF4 is linked to cancer.