It will also be important to better define how CCR8+ Tconv cells contribute to immune regulation in other contexts including infection and inflammation, as clones of Foxp3- CD4+ T cells expressing CCR8, CD25 and IL-10 have previously been described in mice with experimental pulmonary granulomata (72), while CD4+ Tconv cells expressing CCR8 are observed upon experimental allergic lung inflammation in mice (73), and infiltrating human skin (74). This evidence concerns the gene CD4 and infection.