IL10 and neoplasm: Since IL-10 ablation has been shown to promote tumor growth under steady-state conditions (56, 57), we subcutaneously implanted with B16-F10 cells into Il10flox/floxCd4CreFoxp3EGFP-DTR and littermate Cd4CreFoxp3EGFP-DTR control animals and selected animals with tumors of similar size (range 12 - 64 mm2) at day 10 after tumor implantation for randomization to treatment groups (PBS or DTx).