Early Treg cell ablation (before tumors were palpable) resulted in incomplete rejection of primary tumors, whereas Treg cell depletion in mice with established tumors had little discernible effect upon tumor growth (Fig. 1A), despite near complete ablation of Foxp3-expressing Treg cells within the systemic and intratumoral compartments of DTx-treated mice (Fig. 1B). The gene discussed is FOXP3; the disease is neoplasm.