SIRT1 and Hepatic fibrosis: 2021). As NF-κB is a critical regulator of immune function, SIRT1/NF-κB signaling represents one of the critical cytoprotective mechanisms against various pathophysiological processes such as ulcerative colitis, neurological disorders, liver fibrosis, and sepsis (Liu et al. 2020; Shi et al. 2021; Shin et al. 2021; Tang et al. 2021). Notably, an obvious upregulation of SIRT1 protein was found in the LPS group contradictory to other studies (Mohamed et al. 2021), the defensive action which may be related to the dose and timing of LPS stimulation.