NFKB1 and Sepsis: 2017; Kane and Sinclair 2018). Sirtuins have been confirmed to be key regulators of sepsis through antioxidant, anti-apoptotic, and anti-inflammatory properties (Covarrubias et al. 2021). In this regard, Sirtuin 1 (SIRT1) was recently shown to deacetylate and inactivate transcription factors and coactivators to dampen the inflammatory cascade (Yang et al. 2021). The NF-κB pathway plays a central role in regulating the transcription of inflammatory cytokines and mediators during sepsis (Puri and Naura 2022).