Further mechanistic studies revealed that the CSFV NS4A protein interacts with the E3 ubiquitin ligase tripartite-motif containing 25 (TRIM25) (43, 44), promoted its expression, and targeted it to mediate autophagic degradation of RIPK3 and thereby blocked the progression of necroptosis genesis, achieving persistent viral infection. The gene discussed is TRIM25; the disease is viral infectious disease.