Interestingly, we found in our study that CSFV NS4A protein obviously promoted the expression of trim25 in a dose-dependent manner, while TRIM25 did not play an antiviral role as it did in other virus infections, unexpectedly obviously promoted the infection progress of CSFV, correspondingly, TRIM25 was also able to stabilize the expression of NS4A protein. Here, TRIM25 is linked to infection.