HCN4 and epilepsy: Promising results of ion channel-based gene therapy have previously been reported in the same model of FCD II: a treatment aimed to counteract overexpression of the hyperpolarization-activated cyclic nucleotide–gated potassium channel isoform 4 (HCN4) was effective in reducing seizure occurrence.34 Nevertheless, it remains to be determined whether this treatment’s effectiveness is limited to epilepsies caused by overactivation of mTORC1.