In addition, a number of other risk factors are shared in the development of OA and bladder cancer, such as obesity and metabolic syndrome,50, 51, 52, 53 coffee consumption,33, 54 higher serum IGF‐1 concentration,55, 56, 57 Brazilin,58 Chondromodulin‐1,59 vitamin K‐dependent protein, and GRP/Ucma.60 Here, GRP is linked to obesity due to melanocortin 4 receptor deficiency.