In addition, a number of other risk factors are shared in the development of OA and bladder cancer, such as obesity and metabolic syndrome,50, 51, 52, 53 coffee consumption,33, 54 higher serum IGF‐1 concentration,55, 56, 57 Brazilin,58 Chondromodulin‐1,59 vitamin K‐dependent protein, and GRP/Ucma.60 The gene discussed is IGF1; the disease is obesity due to melanocortin 4 receptor deficiency.