In addition, a number of other risk factors are shared in the development of OA and bladder cancer, such as obesity and metabolic syndrome,50, 51, 52, 53 coffee consumption,33, 54 higher serum IGF‐1 concentration,55, 56, 57 Brazilin,58 Chondromodulin‐1,59 vitamin K‐dependent protein, and GRP/Ucma.60 This evidence concerns the gene IGF1 and metabolic syndrome.