Patients with ERBB2 overexpression tended to develop CBC in a shorter time interval compared with patients who had other subtypes; patients with the ERBB2+ subtype had the highest incidence of developing CBC at 4.6 years after surgery for PBC, and the incidence among patients with the HR+/ERBB2– subtype peaked at 7.1 years.9 Here, ERBB2 is linked to primary biliary cholangitis.