ERBB2 and primary biliary cholangitis: In a previous study by some of us,9 young patients (age <35 years) with the ERBB2+ subtype of PBC had the highest risk for CBC at around 4.6 years after PBC surgery, while the risk among young patients with the HR+/ERBB2– subtype peaked at 7.1 years; other patients showed a constant increase over the follow-up period.