Overexpression of ALDH3A1 in melanoma and lung cancer not only regulates tumor cell stemness and the process of EMT, but also promotes inflammation through up-regulation of inflammatory factors such as COX2 and PGE2, and enhances the expression of PD-L1 to affect immune escape (Terzuoli et al., 2019). The gene discussed is CD274; the disease is lung carcinoma.