The IHC results showed that ITGA6 only scattered expression in the basal layer of the normal skin tissue and was up-regulated in SCCIS (p<0.05) and invasive cSCC (p<0.001), as well as being expressed at a higher level in invasive cSCC than in SCCIS (p<0.001, Figure 4J). Here, ITGA6 is linked to skin squamous cell carcinoma.