ISG15 and neoplasm: Based on above differential gene expression and functional enrichment analysis, we identified a group of important candidate genes that may be closely related to tumor genesis and development in cSCC including CD74, CDKN2A, COL17A1, JUND, MMP1, BST2, LGALS1, IFITM3, ISG15, IFI6, FTH1, LAMA3, LAMC2, SAT1, and so on (Figure 5—figure supplement 3B).