For example, as well-known driver genes in cSCC, TP63, and TP53 were detected an enrichment of their binding motifs within DAR in major keratinocytes (Figure 8—figure supplement 2D and Supplementary file 1w) that was supported by increased chromatin accessibility and increased transcription in the scRNA-seq of them. The gene discussed is TP53; the disease is skin squamous cell carcinoma.