The activator protein-1 (AP-1) family transcription factor subunit gene FOS-like 1 (FOSL1) is considered to be the potential driver of transformation from SCCIS to cSCC and is selectively highly expressed at the frontier of invasion in cSCC tumor cells (Figure 3D; García-Díez et al., 2019). The gene discussed is JUND; the disease is neoplasm.