The results showed that after knocking down LGALS1, IFITM3, BST2, and SAT1, the migration distances of A431, SCL-I, and SCL-II tumor cells were reduced after 72 hr of scratching compared with the control group (p<0.01); the tumor cells’ migration ability was decreased, while there was no significant difference with FTH1 in any tumor cells (p>0.05) (Figure 6D and Figure 6—figure supplement 1D). The gene discussed is BST2; the disease is neoplasm.