We further compared the differential genes between the OVXDF and OVX groups and between the OVX and SHAM groups in the osteoporosis model rats after treatment (i.e., PLTP, PON1, NDUFA5, SLC4A1, TNPO1, RAP1B, A1M, TFRC, AFM, PARP14, CRIP1, CZIB, CCDC25, MMP2, LGALS1, FABP5, PIN1, PDGFRL, ST13, LIMA1, IKBIP, SORBS1, SLC9A3R2, PPP1R12B, ERC1, DBI, NQO2). The gene discussed is RAP1B; the disease is osteoporosis.