We further compared the differential genes between the OVXDF and OVX groups and between the OVX and SHAM groups in the osteoporosis model rats after treatment (i.e., PLTP, PON1, NDUFA5, SLC4A1, TNPO1, RAP1B, A1M, TFRC, AFM, PARP14, CRIP1, CZIB, CCDC25, MMP2, LGALS1, FABP5, PIN1, PDGFRL, ST13, LIMA1, IKBIP, SORBS1, SLC9A3R2, PPP1R12B, ERC1, DBI, NQO2). Here, NHERF2 is linked to osteoporosis.