In the syngeneic murine colon carcinoma (MC38) model, although primary tumor growth in Tgfbr2-cKO mice was slower than that in WT mice, local IR resulted in a more pronounced inhibition of tumor growth in Tgfbr2-cKO mice (Supplemental Figure 5C). The gene discussed is TGFBR2; the disease is colon carcinoma.